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Acepromazine is a commonly used pre-anesthetic agent and sedative in canine medicine.

Side-effects have been reported in multi-drug sensitivity breeds such as the Collie, including hypothermia and prolonged recovery.

Acepromazine has been shown to lower ictal thresholds, raising the risk of peri-operative seizures in canine patients[1]. At risk patients should be treated with diazepam or low doses of ketamine[2].

Recommended dose rate is 0.02 mg/kg given orally, SQ, IM or IV as a single dose or repeated very 6 - 8 hours as needed.


  1. Lervik A et al (2010) Abnormal motor activity during anaesthesia in a dog: a case report. Acta Vet Scand 52:64
  2. Serrano S et al (2006) Use of ketamine for the management of refractory status epilepticus in a dog. J Vet Intern Med 20:194–197