Difference between revisions of "Acidophil hepatitis"

From Dog
m (1 revision)
 
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:
 
[[Image:acidophil01.jpg|thumb|Acute hepatitis associated with acidophil cell inclusion bodies]]
 
[[Image:acidophil01.jpg|thumb|Acute hepatitis associated with acidophil cell inclusion bodies]]
 +
Acidophil hepatitis is a rare [[hepatitis|liver disease]] of dogs characterized by chronic hepatitis and fibrosis<ref>Jarrett WF ''et al'' (1997) Persistent hepatitis and chronic fibrosis induced by canine acidophil cell hepatitis virus. ''Vet Rec'' '''120(10)''':234-235</ref>.
  
Acidophil hepatitis is a rare liver disease of dogs, thought to be caused by an unspecified virus which results in acute or chronic hepatitis.
+
The cause of this disease is unknown, but a viral etiology is suspected as [[canine herpesvirus]] affects neonatal puppies, causing hepatic necrosis as well as other systemic changes, and is fatal<ref>Jarrett WF, O'Neil BW, Lindholm I. (1987) Persistent hepatitis and chronic fibrosis induced by canine acidophil cell hepatitis virus. ''Vet Rec'' '''120(10)''':234-5</ref>.
  
Acidophil hepatitis has been reported in dogs in Great Britain, characterized by the histopathologic presence of acidophil cells. Chronic active hepatitis and sometimes hepatocellular carcinoma may occur. The cause is unknown, but a viral etiology is suspected. Differential diagnosis of other cause of chronic hepatitis include canine adenovirus type 1 (CAV-1) and [[Leptospirosis|Leptospira interrogans var. grippotyphosa]].  
+
Acidophil hepatitis has been reported in dogs in Great Britain, characterized by the histopathologic presence of acidophil cells. Chronic active hepatitis and sometimes [[Hepatic carcinoma|hepatocellular carcinoma]] may occur.  
  
Clinical disease varies from acute hepatitis that is severe and fatal to chronic hepatitis and eventually cirrhosis. Intermittent fevers and spikes in ALT levels are noted in chronic disease. Prognosis is poor, and treatment consists of supportive care. Canine herpesvirus affects neonatal puppies, causing hepatic necrosis as well as other systemic changes, and is fatal<ref>Jarrett WF, O'Neil BW, Lindholm I. (1987) Persistent hepatitis and chronic fibrosis induced by canine acidophil cell hepatitis virus. ''Vet Rec'' '''120(10)''':234-5</ref>.
+
Clinical disease varies from acute hepatitis that is severe and fatal to chronic hepatitis and eventually cirrhosis. Intermittent fevers and spikes in [[ALT]] levels are noted in chronic disease.  
  
Several noninfectious causes of canine chronic liver disease have been reported and classified in different etiologic categories, including copper associated, breed associated, drug associated, alpha-1-antitrypsin deficiency associated, and autoimmune chronic hepatitis. Most of these causes, including acidophil hepatitis, share common histologic features that include piecemeal necrosis (periportal necrosis or apoptosis) and progressive fibrosis that eventually leads to cirrhosis. Descriptive histomorphologic terms such as chronic active hepatitis, chronic progressive hepatitis, and lobular dissecting hepatitis have also been used to classify canine chronic hepatitis. However, except for the Bedlington terrier, in which an inherited genetic copper metabolism defect has been demonstrated, the majority of canine chronic liver diseases are idiopathic (unknown cause). Morphological features are not cause specific and infectious agent or noninfectious causes cannot be identified with routine diagnostic tools<ref>Chouinard, M ''et al'' (1998) Use of polymerase chain reaction and immunohistochemistry for detection of canine adenovirus type 1 in formalin-fixed, paraffin-embedded liver of dogs with chronic hepatitis or cirrhosis. ''J Vet Diagn Invest'' '''10''':320-5</ref>.
+
Diagnosis is determined primarily by histopathological examination of liver biopsy.
  
 +
A differential diagnosis would include [[Chronic Hepatitis of Bedlington Terriers|Bedlington terrier hepatitis]] and [[canine adenovirus]] (CAV-1) and ''[[Leptospira spp|Leptospira interrogans]]'' infections<ref>Chouinard, M ''et al'' (1998) Use of polymerase chain reaction and immunohistochemistry for detection of canine adenovirus type 1 in formalin-fixed, paraffin-embedded liver of dogs with chronic hepatitis or cirrhosis. ''J Vet Diagn Invest'' '''10''':320-5</ref>.
 +
 +
There is no specific treatment for this disease and prognosis is poor.
 
==References==
 
==References==
 
<References/>
 
<References/>

Latest revision as of 00:52, 21 February 2013

Acute hepatitis associated with acidophil cell inclusion bodies

Acidophil hepatitis is a rare liver disease of dogs characterized by chronic hepatitis and fibrosis[1].

The cause of this disease is unknown, but a viral etiology is suspected as canine herpesvirus affects neonatal puppies, causing hepatic necrosis as well as other systemic changes, and is fatal[2].

Acidophil hepatitis has been reported in dogs in Great Britain, characterized by the histopathologic presence of acidophil cells. Chronic active hepatitis and sometimes hepatocellular carcinoma may occur.

Clinical disease varies from acute hepatitis that is severe and fatal to chronic hepatitis and eventually cirrhosis. Intermittent fevers and spikes in ALT levels are noted in chronic disease.

Diagnosis is determined primarily by histopathological examination of liver biopsy.

A differential diagnosis would include Bedlington terrier hepatitis and canine adenovirus (CAV-1) and Leptospira interrogans infections[3].

There is no specific treatment for this disease and prognosis is poor.

References

  1. Jarrett WF et al (1997) Persistent hepatitis and chronic fibrosis induced by canine acidophil cell hepatitis virus. Vet Rec 120(10):234-235
  2. Jarrett WF, O'Neil BW, Lindholm I. (1987) Persistent hepatitis and chronic fibrosis induced by canine acidophil cell hepatitis virus. Vet Rec 120(10):234-5
  3. Chouinard, M et al (1998) Use of polymerase chain reaction and immunohistochemistry for detection of canine adenovirus type 1 in formalin-fixed, paraffin-embedded liver of dogs with chronic hepatitis or cirrhosis. J Vet Diagn Invest 10:320-5