Acidophil hepatitis has been reported in dogs in Great Britain, characterized by the histopathologic presence of acidophil cells. Chronic active hepatitis and sometimes hepatocellular carcinoma may occur.
Clinical disease varies from acute hepatitis that is severe and fatal to chronic hepatitis and eventually cirrhosis. Intermittent fevers and spikes in ALT levels are noted in chronic disease.
Diagnosis is determined primarily by histopathological examination of liver biopsy.
There is no specific treatment for this disease and prognosis is poor.
- Jarrett WF et al (1997) Persistent hepatitis and chronic fibrosis induced by canine acidophil cell hepatitis virus. Vet Rec 120(10):234-235
- Jarrett WF, O'Neil BW, Lindholm I. (1987) Persistent hepatitis and chronic fibrosis induced by canine acidophil cell hepatitis virus. Vet Rec 120(10):234-5
- Chouinard, M et al (1998) Use of polymerase chain reaction and immunohistochemistry for detection of canine adenovirus type 1 in formalin-fixed, paraffin-embedded liver of dogs with chronic hepatitis or cirrhosis. J Vet Diagn Invest 10:320-5