Aurothioglucose

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Aurothioglucose is a gold-based glucose derivative with immunomodulatory properties.

This compound is sometimes used for osteoarthritis or unresponsive pemphigus foliaceus[1][2], but has a variability in response with canine patients[3], with only 30% of penphigus patients responding to sole aurothioglucose therapy[4].

Thrombocytopenia and megakaryocytosis have been reported side-effects with use of this drug in dogs[5].

Recommended dose rate is 1 - 2 mg/kg weekly, often used in conjunction with tapering doses of prednisolone.

References

  1. High M (1999) An interesting case of pemphigus foliaceus in a dog. Can Vet J 40(2):127-128
  2. Olynyk GP & Guthrie BJ (1984) Canine pemphigus vulgaris treated with gold salt therapy. Can Vet J 25(4):168-170
  3. Bloom JC et al (1988) The effect of longterm treatment with auranofin and gold sodium thiomalate on immune function in the dog. J Rheumatol 15(3):409-417
  4. Ihrke PJ et al (1985) Pemphigus foliaceus in dogs: a review of 37 cases. J Am Vet Med Assoc 186(1):59-66
  5. Bloom JC et al (1985) Gold-induced immune thrombocytopenia in the dog. Vet Pathol 22(5):492-499