This drug appears to be well tolerated in dogs, with few side-effects.
Recommended dose rate in dogs is 3 mg/m2 given intramuscularly.
- Lewis DH et al (2010) Use of calcium folinate in the management of accidental methotrexate ingestion in two dogs. J Am Vet Med Assoc 237(12):1450-1454
- Cotter SM & Parker LM (1978) High-dose methotrexate and leucovorin rescue in dogs with osteogenic sarcoma. Am J Vet Res 39(12):1943-1945