Clofazimine

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Clofazimine is a fat-soluble riminophenazine dye used in combination with rifampicin, moxifloxacin and dapsone as part of a multidrug therapy for canine mycobacterial granulomas[1].

Clofazimine is highly lipophilic and possesses and unusually long pharmacokinetic half-life of up to 70 days[2] associated with extensive accumulation of the drug in the body[3].

Although not always successful in chronic cases[4], it has also been used as a topical formulation in petroleum jelly as an adjunct to oral rifampicin and doxycycline in mycobacterial granulomas[5].

Recommended dose rate in dogs is 4 - 8 mg/kg given orally every 24 hours for 6 weeks.

References

  1. Malik R et al (2013) Ulcerated and nonulcerated nontuberculous cutaneous mycobacterial granulomas in cats and dogs. Vet Dermatol 24(1):146-153
  2. Banerjee DK et al (1974) Some observations on the pharmacology of clofazimine (B663). Am J Trop Med Hyg 23:1110–1115
  3. Atkinson AJ et al (1967) Evaluation of B.663 in human leprosy. Int J Lepr Other Mycobact Dis 35:119–127
  4. Miller MA et al (1995) Disseminated Mycobacterium avium--intracellulare complex infection in a miniature schnauzer. J Am Anim Hosp Assoc 31(3):213-216
  5. Malik R et al (2001) Treatment of canine leproid granuloma syndrome: preliminary findings in seven dogs. Aust Vet J 79(1):30-36