A variant of this condition is color dilution alopecia (black hair follicular dysplasia).
An hereditary form of follicular dysplasia is color dilution alopecia, characteristically seen in the Doberman, is caused by one or more mutations within or near the MLPH gene. In these cases, permanent hypotrichosis, limited to the dorsolumbar region and sides of the trunk is seen. The hypotrichosis begins at approximately the age of 2 years and progresses slowly with no skin hyperpigmentation. Other breeds are also affected such as the Boston Terrier.
Black hair follicular dysplasia (BHFD) is a variant form of color dilution alopecia which primarily affects the Munsterlander, Huntaway, Jack Russell Terrier, Papillon, Gordon Setter, Saluki and Bearded Collie. This condition is characterized by a specific pigmentation phenotype and sometimes accompanied by hair loss and recurrent skin inflammation.
Canine black hair follicular dysplasia is a rare disorder confined to black coat regions affecting bicolor or tricolor animals within the first few weeks of life. Lesions are characterized by dull, dry, lusterless hair, hair fracture, hypotrichosis and scaliness. An autosomal recessive mode of inheritance has been determined for the Large Münsterländer. Histopathology is characterized by accumulation of melanin clumps within hair shafts, follicular lumina, root sheaths and hair bulbs. Hair shafts are irregular, bulging or replaced by keratinous debris.
Treatment may require broad-spectrum antimicrobials if microbial cultures reveals bacterial infection.
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