Difference between revisions of "Diphenoxylate"

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(Created page with "Diphenoxylate is an opioid agonist that works similar in action on the gastrointestinal tract to loperamide, resulting in delayed peristalsis<ref>Mir GN ''et al'' (1978) I...")
 
 
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Diphenoxylate is an opioid agonist that works similar in action on the gastrointestinal tract to [[loperamide]], resulting in delayed peristalsis<ref>Mir GN ''et al'' (1978) In vivo antimotility and antidiarrheal activity of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent. Comparison with diphenoxylate and loperamide. ''Arzneimittelforschung'' '''28(8a)''':1448-1454</ref>.
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Diphenoxylate is an opioid agonist that works similar in action on the gastrointestinal tract to [[morphine]]<ref>Dajani EZ ''et al'' (1975) Effects of E prostaglandins, diphenoxylate and morphine on intestinal motility in vivo. ''Eur J Pharmacol'' '''34(1)''':105-113</ref> and [[loperamide]]<ref>Mir GN ''et al'' (1978) In vivo antimotility and antidiarrheal activity of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent. Comparison with diphenoxylate and loperamide. ''Arzneimittelforschung'' '''28(8a)''':1448-1454</ref>, resulting in delayed peristalsis.
  
 
It is commonly used in dogs with chronic diarrhea associated with [[ulcerative colitis]].
 
It is commonly used in dogs with chronic diarrhea associated with [[ulcerative colitis]].
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Recommended dose rate in dogs is 0.05 - 0.1 mg/kg given orally every 12 hours.
  
 
==References==
 
==References==
 
<References/>
 
<References/>

Latest revision as of 03:16, 9 April 2013

Diphenoxylate is an opioid agonist that works similar in action on the gastrointestinal tract to morphine[1] and loperamide[2], resulting in delayed peristalsis.

It is commonly used in dogs with chronic diarrhea associated with ulcerative colitis.

Recommended dose rate in dogs is 0.05 - 0.1 mg/kg given orally every 12 hours.

References

  1. Dajani EZ et al (1975) Effects of E prostaglandins, diphenoxylate and morphine on intestinal motility in vivo. Eur J Pharmacol 34(1):105-113
  2. Mir GN et al (1978) In vivo antimotility and antidiarrheal activity of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent. Comparison with diphenoxylate and loperamide. Arzneimittelforschung 28(8a):1448-1454