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Diphenoxylate is an opioid agonist that works similar in action on the gastrointestinal tract to morphine[1] and loperamide[2], resulting in delayed peristalsis.

It is commonly used in dogs with chronic diarrhea associated with ulcerative colitis.

Recommended dose rate in dogs is 0.05 - 0.1 mg/kg given orally every 12 hours.


  1. Dajani EZ et al (1975) Effects of E prostaglandins, diphenoxylate and morphine on intestinal motility in vivo. Eur J Pharmacol 34(1):105-113
  2. Mir GN et al (1978) In vivo antimotility and antidiarrheal activity of lidamidine hydrochloride (WHR-1142A), a novel antidiarrheal agent. Comparison with diphenoxylate and loperamide. Arzneimittelforschung 28(8a):1448-1454