Difference between revisions of "Eosinophilic bronchopneumopathy"

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Eosinophilic bronchopneumopathy is a relatively uncommon [[respiratory disease]] of dogs characterized by [[eosinophilia]] and bronchiectasis.
 
Eosinophilic bronchopneumopathy is a relatively uncommon [[respiratory disease]] of dogs characterized by [[eosinophilia]] and bronchiectasis.
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The cause of this condition is thought to be a hypersensitivity to inhaled allergens is suspected, particularly fungi, drugs, bacteria and parasites.
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Persistent antigenic exposure is thought to result in chronic irritation of the tracheal and bronchial mucous membranes and inflammation, with eventual epithelial desquamation, hyperplasia of the mucous glands, and airway obstruction. These changes impair mucociliary clearance and predispose to secondary bacterial infections, ultimately resulting in bronchiectasis. The increase in intrapulmonary pressures created by coughing against the partially obstructed airways also contributes to destruction of the elastic and muscular layers of the bronchial wall<ref>Clercx C ''et al'' (2000) Eosinophilic bronchopneumopathy in dogs. ''J Vet Internal Med'' '''14''':282–291</ref>.
  
 
Affected dogs usually present with chronic coughing unresponsive to conservative palliative treatment.
 
Affected dogs usually present with chronic coughing unresponsive to conservative palliative treatment.

Revision as of 20:57, 10 February 2013

Eosinophilicbroncho01.jpg

Eosinophilic bronchopneumopathy is a relatively uncommon respiratory disease of dogs characterized by eosinophilia and bronchiectasis.

The cause of this condition is thought to be a hypersensitivity to inhaled allergens is suspected, particularly fungi, drugs, bacteria and parasites.

Persistent antigenic exposure is thought to result in chronic irritation of the tracheal and bronchial mucous membranes and inflammation, with eventual epithelial desquamation, hyperplasia of the mucous glands, and airway obstruction. These changes impair mucociliary clearance and predispose to secondary bacterial infections, ultimately resulting in bronchiectasis. The increase in intrapulmonary pressures created by coughing against the partially obstructed airways also contributes to destruction of the elastic and muscular layers of the bronchial wall[1].

Affected dogs usually present with chronic coughing unresponsive to conservative palliative treatment.

Diagnosis is by demonstration of an eosinophilic inflammatory cell infiltrate within respiratory tract cytological specimens (tracheal wash or bronchoalveolar lavage fluid)[2].

References

  1. Clercx C et al (2000) Eosinophilic bronchopneumopathy in dogs. J Vet Internal Med 14:282–291
  2. Clercx C & Peeters D (2007) Canine eosinophilic bronchopneumopathy. Vet Clin North Am Small Anim Pract 37:917–935