Eosinophilic cellulitis

From Dog

Eosinophilic cellulitis is a rare idiopathic dermatological disorder of dogs characterized by nodular dermatitis, cellulitis and eosinophilia.

This syndrome, which resembles Wells' syndrome in humans, appears to involve erythematous lesions (macules, papules or plaques) that are most pronounced on the abdomen, and lacking the presence of folliculitis or furunculosis[1]. More systemic signs include vomiting and/or diarrhoea and sometimes hematochezia or hematemesis.

In some patients, this may be a skin manifestation of underlying hypereosinophilic syndrome.

Histopathologic features include a profound eosinophilic dermal infiltrate, focal areas of collagen fiber degeneration surrounded by eosinophils (flame figures), dilated vessels, and dermal edema[2].

Initial responses have been reported with use of marbofloxacin and prednisolone which later relapse and progress to generalized cellulitis[3].


  1. Mauldin EA et al (2006) Comparison of clinical history and dermatologic findings in 29 dogs with severe eosinophilic dermatitis: a retrospective analysis. Vet Dermatol 17(5):338-347
  2. Holm KS et al (1999) Eosinophilic dermatitis with edema in nine dogs, compared with eosinophilic cellulitis in humans. J Am Vet Med Assoc 215(5):649-653
  3. Glardon O & Pin D (2010) Diagnosis and therapy of a dog with an atypical eosinophilic cellulitis. Schweiz Arch Tierheilkd 152(11):528-532