Eosinophilic granulomatous gastroenterocolitis

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Eosinophilic granulomatous gastroenterocolitis is an inflammatory bowel disease of dogs characterized by diffuse intestinal thickening and eosinophilic enteritis of the stomach, jejunum, ileum, colon.

Rarely, eosinophilic masses have been reported[1].

Middle-aged Rottweiler and purebred, large breed dogs appear to be predisposed. Concurrent eosinophilic granulomatous gastroenterocolitis and hepatitis have been reported in younger dogs[2].

Clinical signs include chronic intermittent anorexia, vomiting, diarrhea and hematochezia.

An abdominal or rectal mass is frequently noted on physical examination.

Hematological aberrations include peripheral eosinophilia, mature neutrophilia, hypoproteinemia, and hypocholesterolemia.

Histologically, the masses are composed of moderate to severe eosinophilic infiltrates, which were often transmural and accompanied by fibrosis.

A differential diagnosis would include gastrointestinal stromal tumor, pancreatic exocrine insufficiency and intestinal lymphoma.

Dog should not be treated surgically, as they are accompanied with a poor prognosis, but conservative treatment with prednisolone and ivermectin offers palliative responses with eventual resolution of clinical signs.

References

  1. Lyles SE et al (2009) Idiopathic eosinophilic masses of the gastrointestinal tract in dogs. J Vet Intern Med 23(4):818-823
  2. Brellou GD et al (2006) Eosinophilic granulomatous gastroenterocolitis and hepatitis in a 1-year-old male Siberian Husky. Vet Pathol 43(6):1022-1025