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Esmolol is a selective β1 antagonist with rapid onset and short duration.

In dogs, it is commonly used to treat tachycardia associated with drug overdoses (e.g. phenylpropanolamine)[1].

Recommended dose rate in dogs is 0.05 mg/kg given intravenously as a loading dose, followed by 50 - 200 µg/kg per min[2].


  1. Ginn JA et al (2013) Systemic hypertension and hypertensive retinopathy following PPA overdose in a dog. J Am Anim Hosp Assoc 49(1):46-53
  2. Hori, Y et al (2009) The relationship between invasive hemodynamic measurements and tissue Doppler-derived myocardial velocity and acceleration during isovolumic relaxation in healthy dogs. J Vet Med Sci 71(11):1419-1425