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Esmolol is a selective β1 antagonist with rapid onset and short duration.

Administration of this drug usually results in rapid hypotensive effects due to reduced cardiac contractility without appreciable changes in heart rate or systemic vascular resistance[1].

In dogs, it is commonly used to treat tachycardia associated with drug overdoses (e.g. phenylpropanolamine)[2].

Recommended dose rate in dogs is 0.05 mg/kg given intravenously as a loading dose, followed by 50 - 200 µg/kg per min[3].


  1. Masuda R & Takeda S (2008) Responses of hemodynamics and splanchnic organ blood flow to esmolol during inhalation of volatile anesthetics in dogs. Masui 57(1):69-75
  2. Ginn JA et al (2013) Systemic hypertension and hypertensive retinopathy following PPA overdose in a dog. J Am Anim Hosp Assoc 49(1):46-53
  3. Hori, Y et al (2009) The relationship between invasive hemodynamic measurements and tissue Doppler-derived myocardial velocity and acceleration during isovolumic relaxation in healthy dogs. J Vet Med Sci 71(11):1419-1425