Fibronioid leukodystrophy is a rare genetic disease of dogs characterised by localized disease of the white matter of the cerebellum and brain stem.
Clinical symptoms include weight loss, mental depression, anorexia, generalized weakness and vomiting. Neurological signs are inconsistent but may include progressive tetraparesis and tremors, particularly of the hind limbs.
Diagnosis usually requires pre- or postmortem brain biopsy and use of immunohistochemistry for detection of glial fibrillary acidic protein (Rosenthal fibers throughout the white matter) is required for a definitive diagnosis. Dystrophic astrocytes, enlarged with abundant RF particles, is characteristic of this disease.
A differential diagnosis include canine distemper virus.
Treatment responses to prednisolone are poor and the disease invariably progresses, requiring euthanasia.
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