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Flumazenil is a benzodiazepine antagonist used following general anesthesia-use of diazepam or other related drugs[1].

This drug is also used in canine medicine for treatment of diazepam or alprazolam toxicosis[2].

Recommended dose rate in dogs is 0.5 mg/kg given as a single intravenous injection[3].


  1. Unkel JH et al (2006) A comparison of 3 routes of flumazenil administration to reverse benzodiazepine-induced desaturation in an animal model. Pediatr Dent 28(4):357-362
  2. Hellyer PW et al (2001) Effects of diazepam and flumazenil on minimum alveolar concentrations for dogs anesthetized with isoflurane or a combination of isoflurane and fentanyl. Am J Vet Res 62(4):555-560
  3. Sloan JW et al (1990) Dependence-producing properties of alprazolam in the dog. Pharmacol Biochem Behav 35(3):651-657