This drug is a synthetic glucocorticoid which closely resembling endogenous cortisol in dogs.
Long term used of this drug results in reversible increases in glomerular filtration rates, leading to polyuria and polydipsia. Centrla effects lead to polyphagia and reduction in new hair growth can lead to skin abnormalities such as alopecia.
However, a recently developed 0.0584% hydrocortisone aceponate as a topical diester formula spray has however shown benefit in dogs with atopy, flea allergy dermatitis and chronic otitis externa.
This enhances its accumulation in the epidermis-dermis without entering the blood circulation. In recent studies, HCA was show to be very well tolerated and the repeated use of the HCA had no observable adverse reactions over 70 days in dogs.
Recommended dose rate of oral hydrocortisone is 8.5 mg/kg given once daily.
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