Difference between revisions of "Methotrexate"

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(Created page with "__NOTOC__ Methotrexate is an antimetabolite chemotherapy drug. This drug is rarely used alone and is used in treatment of lymphoma in combination with L-asparaginase,...")
 
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This drug is rarely used alone and is used in treatment of [[lymphoma]] in combination with [[L-asparaginase]], [[vincristine]], [[cyclophosphamide]], [[doxorubicin]] and [[prednisolone]]<ref>Simon D ''et al'' (2008) Efficacy of a continuous, multiagent chemotherapeutic protocol versus a short-term single-agent protocol in dogs with lymphoma. ''J Am Vet Med Assoc'' '''232(6)''':879-885</ref>.
 
This drug is rarely used alone and is used in treatment of [[lymphoma]] in combination with [[L-asparaginase]], [[vincristine]], [[cyclophosphamide]], [[doxorubicin]] and [[prednisolone]]<ref>Simon D ''et al'' (2008) Efficacy of a continuous, multiagent chemotherapeutic protocol versus a short-term single-agent protocol in dogs with lymphoma. ''J Am Vet Med Assoc'' '''232(6)''':879-885</ref>.
  
The main side-effects of this drug are vomiting and diarrhea, and in some dogs, a [[protein-losing enteropathy]] may ensue, requiring special attention<ref>Yuki M ''et al'' (2006) A case of protein-losing enteropathy treated with methotrexate in a dog. ''J Vet Med Sci'' '''68(4)''':397-399</ref>.
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The main side-effects of this drug are vomiting, diarrhea and bone marrow suppression<ref>Yu C ''et al'' (2000) Cytotoxic T lymphocyte antigen 4-immunoglobulin fusion protein combined with methotrexate/cyclosporine as graft-versus-host disease prevention in a canine dog leukocyte antigen-nonidentical marrow transplant model. ''Transplantation'' '''69(3)''':450-454</ref>, and in some dogs, a [[protein-losing enteropathy]] may ensue, requiring special attention<ref>Yuki M ''et al'' (2006) A case of protein-losing enteropathy treated with methotrexate in a dog. ''J Vet Med Sci'' '''68(4)''':397-399</ref>.
  
 
High-doses of [[folic acid]] are usually administered to accelerate methotrexate elimination to avoid [[acute renal injury]]<ref>Takeuchi A ''et al'' (2001) Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate. ''Kidney Int'' '''60(3)''':1058-1068</ref>.
 
High-doses of [[folic acid]] are usually administered to accelerate methotrexate elimination to avoid [[acute renal injury]]<ref>Takeuchi A ''et al'' (2001) Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate. ''Kidney Int'' '''60(3)''':1058-1068</ref>.

Revision as of 00:55, 7 March 2013

Methotrexate is an antimetabolite chemotherapy drug.

This drug is rarely used alone and is used in treatment of lymphoma in combination with L-asparaginase, vincristine, cyclophosphamide, doxorubicin and prednisolone[1].

The main side-effects of this drug are vomiting, diarrhea and bone marrow suppression[2], and in some dogs, a protein-losing enteropathy may ensue, requiring special attention[3].

High-doses of folic acid are usually administered to accelerate methotrexate elimination to avoid acute renal injury[4].

References

  1. Simon D et al (2008) Efficacy of a continuous, multiagent chemotherapeutic protocol versus a short-term single-agent protocol in dogs with lymphoma. J Am Vet Med Assoc 232(6):879-885
  2. Yu C et al (2000) Cytotoxic T lymphocyte antigen 4-immunoglobulin fusion protein combined with methotrexate/cyclosporine as graft-versus-host disease prevention in a canine dog leukocyte antigen-nonidentical marrow transplant model. Transplantation 69(3):450-454
  3. Yuki M et al (2006) A case of protein-losing enteropathy treated with methotrexate in a dog. J Vet Med Sci 68(4):397-399
  4. Takeuchi A et al (2001) Role of kidney-specific organic anion transporters in the urinary excretion of methotrexate. Kidney Int 60(3):1058-1068