Methotrexate is an antimetabolite chemotherapy drug.
This drug competitively inhibits dihydrofolic acid reductase, which is normally reduced to tetrahydrofolates in purine nucleotide and thymidine synthesis. Thus, methotrexate interferes with DNA synthesis, repair, and cellular replication.
Recommended dose is 2.5 mg/m2 orally once daily or 5.0 mg/m2 orally on days 1 and 5 of a biweekly maintenance schedule.
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