Miltefosine

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Miltefosine is a phospholipid drug used as both a chemotherapy drug and treatment for canine leishmaniasis.

This drug has been used in combination with marbofloxacin and/or allopurinol, with good efficacy even when used as a stand-alone therapy[1].

The principal drawbacks of miltefosine are teratogenicity, prolonged treatment, high cost and the rapid development of drug resistance[2].

References

  1. Farca AM et al (2012) Canine leishmaniosis: in vitro efficacy of miltefosine and marbofloxacin alone or in combination with allopurinol against clinical strains of Leishmania infantum. Parasitol Res 110(6):2509-2513
  2. Croft SL et al (2006) Drug Resistance in Leishmaniasis. Clin Microbiol Rev 19:111–126