Difference between revisions of "Mitotane"

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Revision as of 21:11, 15 December 2012

Mitotane (Lysodren; o,p'-DDD) is an antineoplastic medication used in the treatment of canine pituitary adenoma or pituitary adenocarcinoma[1].

Mitotane is used in adrenal cancer as adjuvant therapy, monotherapy or combined with other cytotoxic agents in advanced disease.

Side-effects include drug-induced hypoadrenocorticism.

Recommended dose rate in dogs is 50 mg/kg orally once daily for five days, then once weekly maintenance therapy.

References

  1. Reine NJ (2012) Medical management of pituitary-dependent hyperadrenocorticism: mitotane versus trilostane. Top Companion Anim Med 27(1):25-30