Mitotane is used in adrenal cancer as adjuvant therapy, monotherapy or combined with other cytotoxic agents in advanced disease.
Side-effects include drug-induced hypoadrenocorticism.
Recommended dose rate in dogs is 50 mg/kg orally once daily for five days, then once weekly maintenance therapy.
- Reine NJ (2012) Medical management of pituitary-dependent hyperadrenocorticism: mitotane versus trilostane. Top Companion Anim Med 27(1):25-30