Paecilomyces spp

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Paecilomyces spp under light microscopy

Paecilomyces spp are an opportunistic fungal infection of dogs with immunocompromised states.

They are normally considered a non-dermatophytic fungi that requires underlying dermatopathy to invade the skin[1]. The incidence of these infections is greater in warm and humid climate[2].

Species which are pathogenic include:

  • Paecilomyces

Generalized calcinosis cutis, pneumonia[3], discospondylitis and systemic phaeohyphomycosis have been reported with this fungus. In one case focal granulomas were observed in the skin, liver and spleen[4].

Thick walled fungal hyphae are usually detected in impression smears from skin lesions, kidneys, mitral valve, abdominal aorta and vertebral discs[5]. Staining with periodic acid-Schiff's stain is usually confirmatory.

Treatment with generalized phaeohyphomycosis usually requires parenteral ketoconazole[6].

The prognosis for paecilomycosis is poor, although some treatment success has been reported[7].

References

  1. Jand SK & Gupta MP (1989) Dermatomycosis in dogs. Mycoses 32(2):104-105
  2. Philpot CM & Berry AP (1984) The normal fungal flora of dogs. A preliminary report. Mycopathologia 87(3):155-157
  3. Quance-Fitch FJ et al (2002) Pleural effusion in a dog with discospondylitis. Vet Clin Pathol 31(2):69-71
  4. Holahan ML et al (2008) Generalized calcinosis cutis associated with disseminated paecilomycosis in a dog. Vet Dermatol 19(6):368-372
  5. García ME et al (2000) Disseminated mycoses in a dog by Paecilomyces sp. J Vet Med A Physiol Pathol Clin Med 47(4):243-249
  6. Booth MJ et al (2001) Temporary remission of disseminated paecilomycosis in a German shepherd dog treated with ketoconazole. J S Afr Vet Assoc 72(2):99-104
  7. Foley JE et al (2002) Paecilomycosis in dogs and horses and a review of the literature. J Vet Intern Med 16(3):238-243