Difference between revisions of "Paracoccidioides spp"

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''Paracoccidioides spp'' are a dimorphic species of [[fungal infections|yeast]]
 
''Paracoccidioides spp'' are a dimorphic species of [[fungal infections|yeast]]
  
In humans, Paracoccidioides causes a severe systemic mycosis, endemic in Latin America.
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In humans, Paracoccidioides causes a severe systemic mycosis, endemic in Latin America. A similar situation is perceived in these countries, where serological surveys have found more than 50% of urban dogs are seropositive to exposure to this yeast<ref>Fontana FF ''et al'' (2010) Seroepidemiological survey of paracoccidioidomycosis infection among urban and rural dogs from Uberaba, Minas Gerais, Brazil. ''Mycopathologia'' '''169(3)''':159-165</ref>. Co-infection of dogs by ''[[Leishmania spp|Leishmania brasiliensis]]'' is common and may amplify this serological picture<ref>Silveira LH ''et al'' (2006) Serological detection of antibodies against Paracoccidioides brasiliensis in dogs with leishmaniasis. ''Mycopathologia'' '''162(5)''':325-329</ref>. Dogs susceptible to developing leishmaniasis could be also more susceptible to developing paracoccidioidomycosis<ref>Lemesre JL ''et al'' (2005) Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes. ''Vaccine'' '''23''':2825–2840</ref>.
  
Infections in dogs are thought to be naturally acquired via inhalation.
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The ecological niche or exact habitat of the fungus Paracoccidioides brasiliensis is not known, and few isolates have been obtained from the environment<ref>Costa PF ''et al'' (2010) Characteristics of environmental Paracoccidioides brasiliensis isolates. ''Mycopathologia'' '''169(1)''':37-46</ref>. Infections in dogs are thought to be naturally acquired via inhalation.
  
 
Species which are pathogenic in dogs include:
 
Species which are pathogenic in dogs include:
*''''
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*''Paracoccidioides brasiliensis''
  
 
Clinical signs are usually non-specific, although weight loss, hepatomegaly and [[lymphadenopathy]] are consistent findings<ref>de Farias MR ''et al'' (2011) Paracoccidioidomycosis in a dog: case report of generalized lymphadenomegaly. ''Mycopathologia'' '''172(2)''':147-152</ref>.
 
Clinical signs are usually non-specific, although weight loss, hepatomegaly and [[lymphadenopathy]] are consistent findings<ref>de Farias MR ''et al'' (2011) Paracoccidioidomycosis in a dog: case report of generalized lymphadenomegaly. ''Mycopathologia'' '''172(2)''':147-152</ref>.
  
Diagnosis is based on clinical findings, culturing, immunohistochemistry, and histopathology of popliteal lymph nodes.
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Diagnosis is based on clinical findings, culturing, Western blot<ref>Canteros CE ''et al'' (2010) Endemic fungal pathogens in a rural setting of Argentina: seroepidemiological study in dogs. ''Rev Iberoam Micol'' '''27(1)''':14-19</ref>, immunohistochemistry, and histopathology of popliteal lymph nodes.
  
 
[[Itraconazole]] is the drug of choice, with extended treatments for up to 2 years.
 
[[Itraconazole]] is the drug of choice, with extended treatments for up to 2 years.
 
==References==
 
==References==
 
<References/>
 
<References/>

Revision as of 02:00, 18 October 2012

Paracoccidioides01.jpg

Paracoccidioides spp are a dimorphic species of yeast

In humans, Paracoccidioides causes a severe systemic mycosis, endemic in Latin America. A similar situation is perceived in these countries, where serological surveys have found more than 50% of urban dogs are seropositive to exposure to this yeast[1]. Co-infection of dogs by Leishmania brasiliensis is common and may amplify this serological picture[2]. Dogs susceptible to developing leishmaniasis could be also more susceptible to developing paracoccidioidomycosis[3].

The ecological niche or exact habitat of the fungus Paracoccidioides brasiliensis is not known, and few isolates have been obtained from the environment[4]. Infections in dogs are thought to be naturally acquired via inhalation.

Species which are pathogenic in dogs include:

  • Paracoccidioides brasiliensis

Clinical signs are usually non-specific, although weight loss, hepatomegaly and lymphadenopathy are consistent findings[5].

Diagnosis is based on clinical findings, culturing, Western blot[6], immunohistochemistry, and histopathology of popliteal lymph nodes.

Itraconazole is the drug of choice, with extended treatments for up to 2 years.

References

  1. Fontana FF et al (2010) Seroepidemiological survey of paracoccidioidomycosis infection among urban and rural dogs from Uberaba, Minas Gerais, Brazil. Mycopathologia 169(3):159-165
  2. Silveira LH et al (2006) Serological detection of antibodies against Paracoccidioides brasiliensis in dogs with leishmaniasis. Mycopathologia 162(5):325-329
  3. Lemesre JL et al (2005) Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes. Vaccine 23:2825–2840
  4. Costa PF et al (2010) Characteristics of environmental Paracoccidioides brasiliensis isolates. Mycopathologia 169(1):37-46
  5. de Farias MR et al (2011) Paracoccidioidomycosis in a dog: case report of generalized lymphadenomegaly. Mycopathologia 172(2):147-152
  6. Canteros CE et al (2010) Endemic fungal pathogens in a rural setting of Argentina: seroepidemiological study in dogs. Rev Iberoam Micol 27(1):14-19