Difference between revisions of "Paraneoplastic syndrome"

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(Created page with "Paraneoplastic syndromes are a group of noncancerous diseases associated with internal [[cancer|neoplasia<ref>Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and ca...")
 
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Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as hematological aberrations, hormonal changes, or neuromuscular changes (e.g. paraneoplastic [[myasthenia gravis]]<ref>Stepaniuk K ''et al'' (2011) Acquired myasthenia gravis associated with oral sarcoma in a dog. ''J Vet Dent'' '''28(4)''':242-249</ref>).
 
Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as hematological aberrations, hormonal changes, or neuromuscular changes (e.g. paraneoplastic [[myasthenia gravis]]<ref>Stepaniuk K ''et al'' (2011) Acquired myasthenia gravis associated with oral sarcoma in a dog. ''J Vet Dent'' '''28(4)''':242-249</ref>).
  
A significant number of these conditions involve skin pathology, hematological changes such as [[leukocytosis]], [[hypoalbuminemia]], regenerative [[anemia]] and [[hypercalcemia]]<ref>Bergman PJ (2012) Paraneoplastic hypercalcemia. ''Top Companion Anim Med'' '''27(4)''':156-158</ref> as well as general clinical signs of weight loss and anorexia.
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A significant number of these conditions involve skin pathology, hematological changes such as [[leukocytosis]], [[hypoglycemia]], [[hypoalbuminemia]], regenerative [[anemia]] and [[hypercalcemia]]<ref>Bergman PJ (2012) Paraneoplastic hypercalcemia. ''Top Companion Anim Med'' '''27(4)''':156-158</ref> as well as general clinical signs of weight loss and anorexia.
  
 
A number of paraneoplastic skin disorders have been recognized in dogs, including:
 
A number of paraneoplastic skin disorders have been recognized in dogs, including:
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*[[Malignant histiocytosis|Histiocytic sarcoma]]<ref>Soare T ''et al'' (2012) Paraneoplastic syndrome in haemophagocytic histiocytic sarcoma in a dog. ''J Comp Pathol'' '''146(2-3)''':168-174</ref>
 
*[[Malignant histiocytosis|Histiocytic sarcoma]]<ref>Soare T ''et al'' (2012) Paraneoplastic syndrome in haemophagocytic histiocytic sarcoma in a dog. ''J Comp Pathol'' '''146(2-3)''':168-174</ref>
 
*[[Renal carcinoma]]<ref>Petterino C ''et al'' (2011) Paraneoplastic leukocytosis in a dog with a renal carcinoma. ''Vet Clin Pathol'' '''40(1)''':89-94</ref>
 
*[[Renal carcinoma]]<ref>Petterino C ''et al'' (2011) Paraneoplastic leukocytosis in a dog with a renal carcinoma. ''Vet Clin Pathol'' '''40(1)''':89-94</ref>
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*[[Hyperthyroidism]] due to [[thyroid carcinoma]]
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*[[Hyperadrenocorticism]] due to [[adrenal adenocarcinoma]] or [[pituitary adenocarcinoma]].
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*[[Mast cell tumors]]s and secondary [[hypergastrinemia]]
  
 
Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology<ref>Outerbridge CA ''et al' (2013) Cutaneous manifestations of internal diseases. ''Vet Clin North Am Small Anim Pract'' '''43(1)''':135-152</ref>.
 
Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology<ref>Outerbridge CA ''et al' (2013) Cutaneous manifestations of internal diseases. ''Vet Clin North Am Small Anim Pract'' '''43(1)''':135-152</ref>.
 
==References==
 
==References==
 
<References/>
 
<References/>

Revision as of 19:42, 22 February 2013

Paraneoplastic syndromes are a group of noncancerous diseases associated with internal [[cancer|neoplasia[1].

Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as hematological aberrations, hormonal changes, or neuromuscular changes (e.g. paraneoplastic myasthenia gravis[2]).

A significant number of these conditions involve skin pathology, hematological changes such as leukocytosis, hypoglycemia, hypoalbuminemia, regenerative anemia and hypercalcemia[3] as well as general clinical signs of weight loss and anorexia.

A number of paraneoplastic skin disorders have been recognized in dogs, including:

Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology[6].

References

  1. Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. Vet Dermatol 14(6):279-296
  2. Stepaniuk K et al (2011) Acquired myasthenia gravis associated with oral sarcoma in a dog. J Vet Dent 28(4):242-249
  3. Bergman PJ (2012) Paraneoplastic hypercalcemia. Top Companion Anim Med 27(4):156-158
  4. Soare T et al (2012) Paraneoplastic syndrome in haemophagocytic histiocytic sarcoma in a dog. J Comp Pathol 146(2-3):168-174
  5. Petterino C et al (2011) Paraneoplastic leukocytosis in a dog with a renal carcinoma. Vet Clin Pathol 40(1):89-94
  6. Outerbridge CA et al' (2013) Cutaneous manifestations of internal diseases. Vet Clin North Am Small Anim Pract 43(1):135-152