Difference between revisions of "Paraneoplastic syndrome"
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| − | Paraneoplastic syndromes are a group of noncancerous diseases associated with internal [[cancer|neoplasia<ref>Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. ''Vet Dermatol'' '''14(6)''':279-296</ref>. | + | Paraneoplastic syndromes are a group of noncancerous diseases associated with internal [[cancer|neoplasia]]<ref>Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. ''Vet Dermatol'' '''14(6)''':279-296</ref>. |
Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as hematological aberrations, hormonal changes, or neuromuscular changes (e.g. paraneoplastic [[myasthenia gravis]]<ref>Stepaniuk K ''et al'' (2011) Acquired myasthenia gravis associated with oral sarcoma in a dog. ''J Vet Dent'' '''28(4)''':242-249</ref>). | Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as hematological aberrations, hormonal changes, or neuromuscular changes (e.g. paraneoplastic [[myasthenia gravis]]<ref>Stepaniuk K ''et al'' (2011) Acquired myasthenia gravis associated with oral sarcoma in a dog. ''J Vet Dent'' '''28(4)''':242-249</ref>). | ||
| − | A significant number of these conditions involve skin pathology, hematological changes such as [[leukocytosis]], [[hypoglycemia]], [[hypoalbuminemia]], regenerative [[anemia]] and [[hypercalcemia]]<ref>Bergman PJ (2012) Paraneoplastic hypercalcemia. ''Top Companion Anim Med'' '''27(4)''':156-158</ref> as well as general clinical signs of weight loss and anorexia. | + | A significant number of these conditions involve skin pathology, hematological changes such as [[leukocytosis]], [[hypoglycemia]]<ref>Rossi G ''et al'' (2011) Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor-2-producing mammary carcinoma. ''Vet Clin Pathol'' '''39(4)''':480-484</ref>, [[hypoalbuminemia]], regenerative [[anemia]] and [[hypercalcemia]]<ref>Bergman PJ (2012) Paraneoplastic hypercalcemia. ''Top Companion Anim Med'' '''27(4)''':156-158</ref> as well as general clinical signs of weight loss and anorexia. |
A number of paraneoplastic skin disorders have been recognized in dogs, including: | A number of paraneoplastic skin disorders have been recognized in dogs, including: | ||
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*[[Hyperadrenocorticism]] due to [[adrenal adenocarcinoma]] or [[pituitary adenocarcinoma]]. | *[[Hyperadrenocorticism]] due to [[adrenal adenocarcinoma]] or [[pituitary adenocarcinoma]]. | ||
*[[Mast cell tumors]]s and secondary [[hypergastrinemia]] | *[[Mast cell tumors]]s and secondary [[hypergastrinemia]] | ||
| + | *[[mammary tumors|Mammary carcinoma]] | ||
Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology<ref>Outerbridge CA ''et al' (2013) Cutaneous manifestations of internal diseases. ''Vet Clin North Am Small Anim Pract'' '''43(1)''':135-152</ref>. | Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology<ref>Outerbridge CA ''et al' (2013) Cutaneous manifestations of internal diseases. ''Vet Clin North Am Small Anim Pract'' '''43(1)''':135-152</ref>. | ||
==References== | ==References== | ||
<References/> | <References/> | ||
Revision as of 19:44, 22 February 2013
Paraneoplastic syndromes are a group of noncancerous diseases associated with internal neoplasia[1].
Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as hematological aberrations, hormonal changes, or neuromuscular changes (e.g. paraneoplastic myasthenia gravis[2]).
A significant number of these conditions involve skin pathology, hematological changes such as leukocytosis, hypoglycemia[3], hypoalbuminemia, regenerative anemia and hypercalcemia[4] as well as general clinical signs of weight loss and anorexia.
A number of paraneoplastic skin disorders have been recognized in dogs, including:
- Nodular dermatofibrosis
- Feminization syndrome associated with seminomas and sertoli cell tumors
- Superficial necrolytic dermatitis
- Paraneoplastic pemphigus
- Histiocytic sarcoma[5]
- Renal carcinoma[6]
- Hyperthyroidism due to thyroid carcinoma
- Hyperadrenocorticism due to adrenal adenocarcinoma or pituitary adenocarcinoma.
- Mast cell tumorss and secondary hypergastrinemia
- Mammary carcinoma
Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology[7].
References
- ↑ Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. Vet Dermatol 14(6):279-296
- ↑ Stepaniuk K et al (2011) Acquired myasthenia gravis associated with oral sarcoma in a dog. J Vet Dent 28(4):242-249
- ↑ Rossi G et al (2011) Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor-2-producing mammary carcinoma. Vet Clin Pathol 39(4):480-484
- ↑ Bergman PJ (2012) Paraneoplastic hypercalcemia. Top Companion Anim Med 27(4):156-158
- ↑ Soare T et al (2012) Paraneoplastic syndrome in haemophagocytic histiocytic sarcoma in a dog. J Comp Pathol 146(2-3):168-174
- ↑ Petterino C et al (2011) Paraneoplastic leukocytosis in a dog with a renal carcinoma. Vet Clin Pathol 40(1):89-94
- ↑ Outerbridge CA et al' (2013) Cutaneous manifestations of internal diseases. Vet Clin North Am Small Anim Pract 43(1):135-152
