Difference between revisions of "Paraneoplastic syndrome"

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Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as hematological aberrations, hormonal changes, or neuromuscular changes (e.g. paraneoplastic [[myasthenia gravis]]<ref>Stepaniuk K ''et al'' (2011) Acquired myasthenia gravis associated with oral sarcoma in a dog. ''J Vet Dent'' '''28(4)''':242-249</ref>).
 
Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as hematological aberrations, hormonal changes, or neuromuscular changes (e.g. paraneoplastic [[myasthenia gravis]]<ref>Stepaniuk K ''et al'' (2011) Acquired myasthenia gravis associated with oral sarcoma in a dog. ''J Vet Dent'' '''28(4)''':242-249</ref>).
  
A significant number of these conditions involve skin pathology, hematological changes such as [[leukocytosis]], [[hypoglycemia]]<ref>Rossi G ''et al'' (2011) Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor-2-producing mammary carcinoma. ''Vet Clin Pathol'' '''39(4)''':480-484</ref>, [[hypoalbuminemia]], regenerative [[anemia]] and [[hypercalcemia]]<ref>Bergman PJ (2012) Paraneoplastic hypercalcemia. ''Top Companion Anim Med'' '''27(4)''':156-158</ref> as well as general clinical signs of weight loss and anorexia.
+
A significant number of these conditions involve skin pathology, hematological changes such as [[leukocytosis]], [[hypoglycemia]], [[hypoalbuminemia]], regenerative [[anemia]] and [[hypercalcemia]]<ref>Bergman PJ (2012) Paraneoplastic hypercalcemia. ''Top Companion Anim Med'' '''27(4)''':156-158</ref> as well as general clinical signs of weight loss and anorexia.
  
A number of paraneoplastic skin disorders have been recognized in dogs, including:
+
A number of diseases can result in paraneoplastic syndrome, including:
 
*[[Dermatofibrosis|Nodular dermatofibrosis]]
 
*[[Dermatofibrosis|Nodular dermatofibrosis]]
 
*[[Feminization syndrome]] associated with [[seminoma]]s and [[sertoli cell tumor]]s
 
*[[Feminization syndrome]] associated with [[seminoma]]s and [[sertoli cell tumor]]s
*[[Superficial necrolytic dermatitis]]
+
*[[Superficial necrolytic dermatitis]] due to [[glucagonoma]]<ref>Oberkirchner U ''et al'' (2010) Successful treatment of canine necrolytic migratory erythema (superficial necrolytic dermatitis) due to metastatic glucagonoma with octreotide. ''Vet Dermatol'' '''21(5)''':510-516</ref>
 
*[[Pemphigus|Paraneoplastic pemphigus]]
 
*[[Pemphigus|Paraneoplastic pemphigus]]
 
*[[Malignant histiocytosis|Histiocytic sarcoma]]<ref>Soare T ''et al'' (2012) Paraneoplastic syndrome in haemophagocytic histiocytic sarcoma in a dog. ''J Comp Pathol'' '''146(2-3)''':168-174</ref>
 
*[[Malignant histiocytosis|Histiocytic sarcoma]]<ref>Soare T ''et al'' (2012) Paraneoplastic syndrome in haemophagocytic histiocytic sarcoma in a dog. ''J Comp Pathol'' '''146(2-3)''':168-174</ref>
 
*[[Renal carcinoma]]<ref>Petterino C ''et al'' (2011) Paraneoplastic leukocytosis in a dog with a renal carcinoma. ''Vet Clin Pathol'' '''40(1)''':89-94</ref>
 
*[[Renal carcinoma]]<ref>Petterino C ''et al'' (2011) Paraneoplastic leukocytosis in a dog with a renal carcinoma. ''Vet Clin Pathol'' '''40(1)''':89-94</ref>
 
*[[Hyperthyroidism]] due to [[thyroid carcinoma]]
 
*[[Hyperthyroidism]] due to [[thyroid carcinoma]]
*[[Hyperadrenocorticism]] due to [[adrenal adenocarcinoma]] or [[pituitary adenocarcinoma]].
+
*[[Hyperadrenocorticism]] due to [[adrenal adenocarcinoma]] or [[pituitary adenocarcinoma]]
 
*[[Mast cell tumors]]s and secondary [[hypergastrinemia]]
 
*[[Mast cell tumors]]s and secondary [[hypergastrinemia]]
*[[mammary tumors|Mammary carcinoma]]
+
*[[Mammary carcinoma]]<ref>Rossi G ''et al'' (2011) Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor-2-producing mammary carcinoma. ''Vet Clin Pathol'' '''39(4)''':480-484</ref>
 +
*[[Thymoma]]<ref>Batlivala TP ''et al'' (2010) Paraneoplastic T cell lymphocytosis associated with a thymoma in a dog. ''J Small Anim Pract'' '''51(9)''':491-494</ref>
  
 
Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology<ref>Outerbridge CA ''et al' (2013) Cutaneous manifestations of internal diseases. ''Vet Clin North Am Small Anim Pract'' '''43(1)''':135-152</ref>.
 
Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology<ref>Outerbridge CA ''et al' (2013) Cutaneous manifestations of internal diseases. ''Vet Clin North Am Small Anim Pract'' '''43(1)''':135-152</ref>.
 
==References==
 
==References==
 
<References/>
 
<References/>

Revision as of 19:48, 22 February 2013

Paraneoplastic syndromes are a group of noncancerous diseases associated with internal neoplasia[1].

Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as hematological aberrations, hormonal changes, or neuromuscular changes (e.g. paraneoplastic myasthenia gravis[2]).

A significant number of these conditions involve skin pathology, hematological changes such as leukocytosis, hypoglycemia, hypoalbuminemia, regenerative anemia and hypercalcemia[3] as well as general clinical signs of weight loss and anorexia.

A number of diseases can result in paraneoplastic syndrome, including:

Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology[9].

References

  1. Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. Vet Dermatol 14(6):279-296
  2. Stepaniuk K et al (2011) Acquired myasthenia gravis associated with oral sarcoma in a dog. J Vet Dent 28(4):242-249
  3. Bergman PJ (2012) Paraneoplastic hypercalcemia. Top Companion Anim Med 27(4):156-158
  4. Oberkirchner U et al (2010) Successful treatment of canine necrolytic migratory erythema (superficial necrolytic dermatitis) due to metastatic glucagonoma with octreotide. Vet Dermatol 21(5):510-516
  5. Soare T et al (2012) Paraneoplastic syndrome in haemophagocytic histiocytic sarcoma in a dog. J Comp Pathol 146(2-3):168-174
  6. Petterino C et al (2011) Paraneoplastic leukocytosis in a dog with a renal carcinoma. Vet Clin Pathol 40(1):89-94
  7. Rossi G et al (2011) Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor-2-producing mammary carcinoma. Vet Clin Pathol 39(4):480-484
  8. Batlivala TP et al (2010) Paraneoplastic T cell lymphocytosis associated with a thymoma in a dog. J Small Anim Pract 51(9):491-494
  9. Outerbridge CA et al' (2013) Cutaneous manifestations of internal diseases. Vet Clin North Am Small Anim Pract 43(1):135-152