Difference between revisions of "Paraneoplastic syndrome"
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| − | [[File:paraneoplastic01.jpg|[[Hypertrophic osteopathy]] in [[Belgium Shepherd]] with renal pelvic [[transitional cell carcinoma]] <ref name="Gri" />]] | + | [[File:paraneoplastic01.jpg|thumb|[[Hypertrophic osteopathy]] in a [[Belgium Shepherd]] with renal pelvic [[transitional cell carcinoma]] <ref name="Gri" />]] |
Paraneoplastic syndromes are a group of noncancerous diseases associated with internal [[cancer|neoplasia]]<ref>Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. ''Vet Dermatol'' '''14(6)''':279-296</ref>. | Paraneoplastic syndromes are a group of noncancerous diseases associated with internal [[cancer|neoplasia]]<ref>Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. ''Vet Dermatol'' '''14(6)''':279-296</ref>. | ||
Revision as of 21:07, 22 February 2013
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Paraneoplastic syndromes are a group of noncancerous diseases associated with internal neoplasia[2].
Paraneoplastic syndrome commonly presents as dermatological manifestations but can also be evident as cardiac abnormalities (e.g. ventricular tachycardia[3] due to underlying neuroendocrine disease), neuromuscular changes (e.g. paraneoplastic myasthenia gravis[4]), ocular changes (e.g. uveitis[5]), hematological changes (e.g. leukocytosis, eosinophilia, hypoglycemia, hypoalbuminemia, regenerative anemia and hypercalcemia[6]) as well as general clinical signs of weight loss, polyuria, polydipsia, diarrhea and anorexia.
A number of diseases can result in paraneoplastic syndrome, including:
- Nodular dermatofibrosis associated with uterine leiomyomas
- Feminization syndrome associated with seminomas and sertoli cell tumors
- Superficial necrolytic dermatitis due to glucagonoma[7]
- Paraneoplastic pemphigus[8]
- Histiocytic sarcoma[9]
- Renal carcinoma[10] and renal adenocarcinoma
- Hyperthyroidism due to thyroid carcinoma
- Hyperadrenocorticism due to adrenal adenocarcinoma or pituitary adenocarcinoma
- Mast cell tumors and secondary hypergastrinemia
- Mammary carcinoma[11] and secondary polyneuropathy[12]
- Thymoma[13]
- Hypereosinophilic syndrome with T cell lymphoma[14]
- Melanoma and secondary hyperparathyroidism[15]
- Leiomyosarcoma with secondary diabetes insipidus[16]
- transitional cell carcinoma with secondary hypertrophic osteopathy[1]
Differentiating these paraneoplastic skin changes from other skin diseases can be challenging and often requires skin biopsies and blood tests to elucidate the underlying pathology[17].
References
- ↑ 1.0 1.1 Grillo TP et al (2007) Hypertrophic osteopathy associated with renal pelvis transitional cell carcinoma in a dog. Can Vet J 48(7):745-747
- ↑ Turek MM (2003) Cutaneous paraneoplastic syndromes in dogs and cats: a review of the literature. Vet Dermatol 14(6):279-296
- ↑ Tappin S et al (2008) An intestinal neuroendocrine tumour associated with paroxysmal ventricular tachycardia and melaena in a 10-year-old boxer. J Small Anim Pract 49(1):33-37
- ↑ Stepaniuk K et al (2011) Acquired myasthenia gravis associated with oral sarcoma in a dog. J Vet Dent 28(4):242-249
- ↑ Snead EC et al (2005) A case of bilateral renal lymphosarcoma with secondary polycythaemia and paraneoplastic syndromes of hypoglycaemia and uveitis in an English Springer Spaniel. Vet Comp Oncol 3(3):139-144
- ↑ Bergman PJ (2012) Paraneoplastic hypercalcemia. Top Companion Anim Med 27(4):156-158
- ↑ Oberkirchner U et al (2010) Successful treatment of canine necrolytic migratory erythema (superficial necrolytic dermatitis) due to metastatic glucagonoma with octreotide. Vet Dermatol 21(5):510-516
- ↑ Nishifuji K et al (2009) Development of an enzyme-linked immunosorbent assay for detection of circulating IgG autoantibodies against canine desmoglein 3 in dogs with pemphigus. Vet Dermatol 20(5-6):331-337
- ↑ Soare T et al (2012) Paraneoplastic syndrome in haemophagocytic histiocytic sarcoma in a dog. J Comp Pathol 146(2-3):168-174
- ↑ Petterino C et al (2011) Paraneoplastic leukocytosis in a dog with a renal carcinoma. Vet Clin Pathol 40(1):89-94
- ↑ Rossi G et al (2011) Paraneoplastic hypoglycemia in a diabetic dog with an insulin growth factor-2-producing mammary carcinoma. Vet Clin Pathol 39(4):480-484
- ↑ Mariani CL et al (1999) Paraneoplastic polyneuropathy and subsequent recovery following tumor removal in a dog. J Am Anim Hosp Assoc 35(4):302-305
- ↑ Batlivala TP et al (2010) Paraneoplastic T cell lymphocytosis associated with a thymoma in a dog. J Small Anim Pract 51(9):491-494
- ↑ Marchetti V et al (2005) Paraneoplastic hypereosinophilia in a dog with intestinal T-cell lymphoma. Vet Clin Pathol 34(3):259-263
- ↑ Pressler BM et al (2002) Hypercalcemia and high parathyroid hormone-related protein concentration associated with malignant melanoma in a dog. J Am Vet Med Assoc 221(2):263-265
- ↑ Cohen M & Post GS (1999) Nephrogenic diabetes insipidus in a dog with intestinal leiomyosarcoma. J Am Vet Med Assoc 215(12):1818-1820
- ↑ Outerbridge CA et al' (2013) Cutaneous manifestations of internal diseases. Vet Clin North Am Small Anim Pract 43(1):135-152
