Posaconazole

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Posaconazole is an azole drug similar in action to ketoconazole.

It is primarily used against severe fungal infections such as Blastomyces spp[1].

It is also available in a topical ointment containing mometasone furoate (Posatex®)[2], useful against fungal organisms such as Malassezia pachydermatis[3].

Side-effects such as phospholipidosis in neurons has been reported following use of posaconazole, without evidence for functional neurologic effects[4].

Recommended dose rate in dogs is 2.5 - 3.75 mg/kg given orally every 12 hours.

References

  1. López-Martínez R & Méndéz-Tovar LJ (2012) Blastomycosis. Clin Dermatol 30(6):565-572
  2. Emmerich IU (2012) New drugs for small animals in 2011. Tierarztl Prax Ausg K Kleintiere Heimtiere 40(5):351-362
  3. Cafarchia C et al (2012) In vitro evaluation of Malassezia pachydermatis susceptibility to azole compounds using E-test and CLSI microdilution methods. Med Mycol 50(8):795-801
  4. Cartwright ME et al (2009) Phospholipidosis in neurons caused by posaconazole, without evidence for functional neurologic effects. Toxicol Pathol 37(7):902-910