Prazosin is an orally-active uroselective α-1-adrenergic antagonist which acts as a sympatholytic drug on vascular smooth muscle. It has very little α-2 antagonist activity.
Traditionally, the drug of choice for the treatment of functional urethral obstruction in dogs has been phenoxybenzamine, another α-adrenergic antagonist, but has been replaced by prazosin as a more selective α-1 antagonist.
Recommended dose rate in dogs is 20-50 μg/kg.
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