Pyridoxine

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Pyridoxine (3-hydroxy-4,5-dihydroxy-methyl-2-methyl-pyridine; Vitamin B6) is an essential vitamin important for hemosynthesis as well as homeostasis of Na:K levels.

Dogs convert pyridoxine into the enzymatically active form, pyridoxal-5-phosphate, which plays a role in a wide variety of enzyme systems, especially in the metabolic utilization and transformation of amino acids.

Deficiencies result in microcytic microchromic anemia, skin lesions and seizures[1].

It is also used as a rescue remedy for side-effects associated with chemotherapy with use of drugs such as doxil.

Pyridoxine in excess levels (> 150 mg/kg daily for 7 days) is associated with development of a reversible neuropathy in dogs characterized by hindlimb ataxia[2].

References

  1. Rosenberg IH (2012) A history of the isolation and identification of vitamin B(6). Ann Nutr Metab 61(3):236-238
  2. Chung JY et al (2008) In vitro and in vivo gene therapy with CMV vector-mediated presumed dog beta-nerve growth factor in pyridoxine-induced neuropathy dogs. J Vet Sci 9(4):367-373