Pyruvate dehydrogenase phosphatase 1 deficiency

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Pyruvate dehydrogenase phosphatase 1 deficiency is a genetic storage disease characterized by dramatic exercise intolerance and post exercise collapse.

Pyruvate Dehydrogenase Phosphatase 1 is a global mitochondrial enzyme which reverses the effects of pyruvate dehydrogenase kinase upon pyruvate dehydrogenase.

This disease is mainly reported in the Clumber Spaniel and Sussex Spaniel.