Difference between revisions of "Thrombocytopenia"

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*[[Hypoadrenocorticism]]<ref>Snead E ''et al'' (2011) Glucocorticoid-dependent hypoadrenocorticism with thrombocytopenia and neutropenia mimicking sepsis in a Labrador retriever dog. ''Can Vet J'' '''52(10)''':1129-1134</ref>
 
*[[Hypoadrenocorticism]]<ref>Snead E ''et al'' (2011) Glucocorticoid-dependent hypoadrenocorticism with thrombocytopenia and neutropenia mimicking sepsis in a Labrador retriever dog. ''Can Vet J'' '''52(10)''':1129-1134</ref>
 
*[[DIC]]<ref>Botsch V ''et al'' (2009) Retrospective study of 871 dogs with thrombocytopenia. ''Vet Rec'' '''164(21)''':647-651</ref>
 
*[[DIC]]<ref>Botsch V ''et al'' (2009) Retrospective study of 871 dogs with thrombocytopenia. ''Vet Rec'' '''164(21)''':647-651</ref>
*Other immune-medaited diseases - e.g. [[Immune-mediated neutropenia]]<ref>Brown MR  & Rogers KS (2001) Neutropenia in dogs and cats: A retrospective study of 261 cases. ''J Am Anim Hosp Assoc'' '''37''':131–139</ref>, [[Immune-mediated hemolytic anemia]]<ref>Orcutt ES ''et al'' (2010) Immune-mediated hemolytic anemia and severe thrombocytopenia in dogs: 12 cases (2001-2008). ''J Vet Emerg Crit Care (San Antonio)'' '''20(3)''':338-345</ref>, [[lupus erythematosus]]<ref>Joshi BC & Jain NC (1977) Experimental immunologic thrombocytopenia in dogs: a study of thrombocytopenia and megakaryocytopoiesis. ''Res Vet Sci'' '''22''':11–17</ref>
+
*[[Immune-mediated disease]]s - e.g. [[immune-mediated thrombocytopenia]], [[Immune-mediated neutropenia]]<ref>Brown MR  & Rogers KS (2001) Neutropenia in dogs and cats: A retrospective study of 261 cases. ''J Am Anim Hosp Assoc'' '''37''':131–139</ref>, [[Immune-mediated hemolytic anemia]]<ref>Orcutt ES ''et al'' (2010) Immune-mediated hemolytic anemia and severe thrombocytopenia in dogs: 12 cases (2001-2008). ''J Vet Emerg Crit Care (San Antonio)'' '''20(3)''':338-345</ref>, [[lupus erythematosus]]<ref>Joshi BC & Jain NC (1977) Experimental immunologic thrombocytopenia in dogs: a study of thrombocytopenia and megakaryocytopoiesis. ''Res Vet Sci'' '''22''':11–17</ref>
 
*Recent drug therapy - potentiated sulfonamides<ref>Trepanier LA ''et al'' (2003) Clinical findings in 40 dogs with hypersensitivity associated with administration of potentiated sulfonamides. ''J Vet Int Med'' '''17''':647–652</ref>
 
*Recent drug therapy - potentiated sulfonamides<ref>Trepanier LA ''et al'' (2003) Clinical findings in 40 dogs with hypersensitivity associated with administration of potentiated sulfonamides. ''J Vet Int Med'' '''17''':647–652</ref>
 
*Live vaccination administration - this relationship not definitively established in dogs<ref>Huang AA ''et al'' (2012) Idiopathic immune-mediated thrombocytopenia and recent vaccination in dogs. ''J Vet Intern Med'' '''26(1)''':142-148</ref>
 
*Live vaccination administration - this relationship not definitively established in dogs<ref>Huang AA ''et al'' (2012) Idiopathic immune-mediated thrombocytopenia and recent vaccination in dogs. ''J Vet Intern Med'' '''26(1)''':142-148</ref>

Revision as of 18:47, 7 February 2013

Thrombocytopenia in dogs is defined as a reduced levels of circulating thrombocytes (platelets) below the normal cut-off value of 2 x 1011/L.

Causes include:

- Dirofilaria immitis[1], Angiostrongylus vasorum[2][3], Rickettsia spp, Leishmania infantum[4], Ehrlichia canis[5], Borrelia burgdorferi, Babesia rossi[6], Anaplasma phagocytophilum[7]

Diagnosis is one of exclusion

Treatment depends on the underlying cause which should be accurately diagnosed in order to maximize clinical response and survival.

Initial therapy is aimed at ameliorating the coagulopathy with use of intravenous fresh frozen plasma to replace lost thrombocytes.

References

  1. Grindem CB et al (1991) Epidemiologic survey of thrombocytopenia in dogs: a report on 987 cases. Vet Clin Path 20:38–43
  2. Gould SM & McInnes EL (1999) Immune-mediated thrombocytopenia associated with Angiostrongylus vasorum infection in a dog. Journal of Small Animal Practice 40:227–232
  3. O'neill E et al (2010) Immune-mediated thrombocytopenia associated with angiostrongylus vasorum infection in a Jack Russell terrier. Ir Vet J 63(7):434-440
  4. Cortese L et al (2009) Secondary immune-mediated thrombocytopenia in dogs naturally infected by Leishmania infantum. Vet Rec 164(25):778-782
  5. Giudice E et al (2010) Effect of desmopressin on immune-mediated haemorrhagic disorders due to canine monocytic ehrlichiosis: a preliminary study. J Vet Pharmacol Ther 33(6):610-614
  6. Scheepers E et al (2011) Serial haematology results in transfused and non-transfused dogs naturally infected with Babesia rossi. J S Afr Vet Assoc 82(3):136-143
  7. Cockwill KR et al (2009) Granulocytic anaplasmosis in three dogs from Saskatoon, Saskatchewan. Can Vet J 50:835–840
  8. Schnier LM (2010) A case of splenic torsion with progressive anemia and thrombocytopenia. Can Vet J 51(5):527-529
  9. Snead E et al (2011) Glucocorticoid-dependent hypoadrenocorticism with thrombocytopenia and neutropenia mimicking sepsis in a Labrador retriever dog. Can Vet J 52(10):1129-1134
  10. Botsch V et al (2009) Retrospective study of 871 dogs with thrombocytopenia. Vet Rec 164(21):647-651
  11. Brown MR & Rogers KS (2001) Neutropenia in dogs and cats: A retrospective study of 261 cases. J Am Anim Hosp Assoc 37:131–139
  12. Orcutt ES et al (2010) Immune-mediated hemolytic anemia and severe thrombocytopenia in dogs: 12 cases (2001-2008). J Vet Emerg Crit Care (San Antonio) 20(3):338-345
  13. Joshi BC & Jain NC (1977) Experimental immunologic thrombocytopenia in dogs: a study of thrombocytopenia and megakaryocytopoiesis. Res Vet Sci 22:11–17
  14. Trepanier LA et al (2003) Clinical findings in 40 dogs with hypersensitivity associated with administration of potentiated sulfonamides. J Vet Int Med 17:647–652
  15. Huang AA et al (2012) Idiopathic immune-mediated thrombocytopenia and recent vaccination in dogs. J Vet Intern Med 26(1):142-148
  16. Flatland B et al (2011) May-Hegglin anomaly in a dog. Vet Clin Pathol 40(2):207-214