Difference between revisions of "Thrombopathia"

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Thrombopathia has been reported in the [[Basset Hound]]<ref>Johnstone IB & Lotz F (1979) An inherited platelet function defect in basset hounds. ''Can Vet J'' '''20''':211–215</ref>, [[Spitz]] and [[American Cocker Spaniel]]<ref>Brooks M & Catalfamo J (1993) Buccal mucosa bleeding time is prolonged in canine models of primary hemostatic disorders. ''Thromb Haemost'' '''70(5)''':777-780</ref>.
 
Thrombopathia has been reported in the [[Basset Hound]]<ref>Johnstone IB & Lotz F (1979) An inherited platelet function defect in basset hounds. ''Can Vet J'' '''20''':211–215</ref>, [[Spitz]] and [[American Cocker Spaniel]]<ref>Brooks M & Catalfamo J (1993) Buccal mucosa bleeding time is prolonged in canine models of primary hemostatic disorders. ''Thromb Haemost'' '''70(5)''':777-780</ref>.
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Acquired thrombocytopathia has also been reported in dogs due to ''[[Angiostrongylus spp|Angiostrongylus vasorum]]'', hypergammaglobulinemia associated with [[multiple myeloma]] and [[lymphoma|B-cell lymphoma]] as well as administration of some colloid solutions, non-steroidal anti-inflammatory drugs and cephalosporins.
  
 
Clinical signs are usually absent although buccal bleeding and [[hematochezia]] may be evident.
 
Clinical signs are usually absent although buccal bleeding and [[hematochezia]] may be evident.

Latest revision as of 23:36, 7 March 2013

Thrombopathia is a rare autosomal-recessive genetic form of hemophilia.

This disease is caused by a missense mutation that produces platelets with abnormal fibrinogen receptor exposure and impaired dense granule release, and results in bleeding tendencies primarily of mucosal surfaces.

It is similar in clinical presentation to Glanzmann's thrombasthenia[1].

Thrombopathia has been reported in the Basset Hound[2], Spitz and American Cocker Spaniel[3].

Acquired thrombocytopathia has also been reported in dogs due to Angiostrongylus vasorum, hypergammaglobulinemia associated with multiple myeloma and B-cell lymphoma as well as administration of some colloid solutions, non-steroidal anti-inflammatory drugs and cephalosporins.

Clinical signs are usually absent although buccal bleeding and hematochezia may be evident.

Diagnosis is usually with coagulation screening assays and specialized platelet function testing.

In severely affected patients, intravenous therapy with cryoprecipitates or fresh frozen plasma may be required.

References

  1. Catalfamo JL & Dodds WJ (1988) Hereditary canine thrombopathia. Vet Clin North Am Small Anim Pract 18(1):273-274
  2. Johnstone IB & Lotz F (1979) An inherited platelet function defect in basset hounds. Can Vet J 20:211–215
  3. Brooks M & Catalfamo J (1993) Buccal mucosa bleeding time is prolonged in canine models of primary hemostatic disorders. Thromb Haemost 70(5):777-780