Flunixin meglumine is a nonsteroidal anti-inflammatory drug with both anti-inflammatory and analgesic properties.
Due to its potents COX-1 and COX-2 inhibitory activities, flunixin should be given for less than 5 days to minimize side-effects.
Prolonged used is associated with gastroenteritis, hepatotoxicity, coagulopathy and acute renal injury.
Recommended dose rate in horses is 1.1 - 2.2 mg/kg given intramuscularly or subcutaneously once daily for 3 days, then repeated after 4 days.
- Lees P et al (2004) PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J Vet Pharmacol Ther 27(6):491-502
- Foreman JH et al (2012) Dose titration of the clinical efficacy of intravenously administered flunixin meglumine in a reversible model of equine foot lameness. Equine Vet J Suppl 44(43):17-20