Flunixin meglumine

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Flunixin meglumine is a nonsteroidal anti-inflammatory drug with both anti-inflammatory and analgesic properties.

This drug is primarily used for pain relief associated with laminitis or colic.

Due to its potents COX-1 and COX-2 inhibitory activities[1], flunixin should be given for less than 5 days to minimize side-effects.

Prolonged used is associated with gastroenteritis, hepatotoxicity, coagulopathy and acute renal injury.

Recommended dose rate in horses is 1.1 - 2.2 mg/kg given intramuscularly or subcutaneously once daily for 3 days, then repeated after 4 days[2].

References

  1. Lees P et al (2004) PK-PD integration and PK-PD modelling of nonsteroidal anti-inflammatory drugs: principles and applications in veterinary pharmacology. J Vet Pharmacol Ther 27(6):491-502
  2. Foreman JH et al (2012) Dose titration of the clinical efficacy of intravenously administered flunixin meglumine in a reversible model of equine foot lameness. Equine Vet J Suppl 44(43):17-20